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Indications Citalopram is FDA-approved to treat the following disorders (11): Depression in adults Citalopram is prescribed off-label to treat: Obsessive-compulsive disorder (OCD) Panic disorder Generalized anxiety disorder (GAD) Social anxiety disorder (SAD) Premenstrual dysmorphic disorder (PMDD) Binge eating disorder Posttraumatic stress disorder (PTSD) Premature ejaculation Poststroke depression Mechanisms of Action and Pharmacokinetics Citalopram escalates the brain-derived neurotrophic factor (BDNF) in the hippocampus and prefrontal cortex, which can be decreased in patients with depression (18)