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Enzyme selectivity for cleavage immediately C-terminal to proline or alanine residues at position 2 substrate peptides is dictated by the shape and size of the S1 pocket, which is lined by Val656, Tyr631, Tyr662, Trp659, Tyr666, and Val711 (Figure 6)
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The notorious fen-phen did, indeed, cause serious heart damage and was discontinued after creating a media stir in the 90s
This ambiguity makes them incredibly versatile, perfect for creating ethereal and dreamy soundscapes, moments of suspense, or gentle, floating textures
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