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When GLP-1s were approved for chronic weight management, the intention was for them to be used by overweight individuals at risk of other medical issues

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In contrast, 100 nM exendin 939 application following 10 nM BCTC elicited significant further inhibition of CAP-evoked TRPV1 inward currents (Fig

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Indeed, an important issue for the potential cognitive and mental health effects of GLP-1RAs, which our analysis cannot fully address, is whether these medications provide symptomatic relief only via their well-established cardiometabolic benefits, or by directly targeting physiopathological mechanisms behind cognitive and mental symptoms

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