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ACTH Manufacturing Update Executive Summary NEURACTHEL (ACTH) part of CLINUVELs expanded melanocortin portfolio Drug substance being manufactured under current Good Manufacturing Practices Development and validation work in progress CLINUVEL translates its expertise in melanocortins and formulations CLINUVEL is progressing scaled manufacturing of adrenocorticotropic hormone (ACTH) under current Good Manufacturing Practice (cGMP), as it strives to finalise the development and validation work necessary for a complete regulatory dossier

doi: 10.7860/JCDR/2013/6635.3732 122

CB-839, an inhibitor targeting GLS, has shown good tumor inhibition activity, tolerance, and safety in preclinical studies and phase I clinical trials in solid tumors