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The stirring continued for 1 h at 0 C, an ice-cold solution of SnCl 2 2H 2 O (451 mg, 2 mmol) in 6 M HCl (1 mL) was added, the cooling bath was removed, and the stirring continued for 1 h at room temperature

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How the Three Pathways Work Together What makes the design work is that the three receptor pathways complement each other: GLP-1 reduces energy intake (you eat less) GIP optimizes how that energy is used (better insulin sensitivity, favorable fat distribution) Glucagon increases energy expenditure (you burn more calories at rest and mobilize stored fat) The net effect: you eat less, your body uses energy more efficiently, and you burn more calories at rest