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Risks of Staying in a Calorie Deficit for Too Long Prolonged calorie restriction risks nutritional deficiencies, bone loss, metabolic adaptation, weight cycling, and an association with disordered eating behaviours including binge eating disorder and anorexia nervosa

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FDA encourages patients to talk with their healthcare provider or compounder about how to measure and administer the intended dose of compounded semaglutide, according to the agencys warning

That recommendation applies directly to the first 8-12 weeks of semaglutide therapy