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Preclinical studies in rodent models have examined its interactions with nitric oxide signaling, angiogenic factors including VEGF, fibroblast migration, and collagen synthesis in various tissue types

Additionally, an increase in TSPO binding is not seen in patients with age-related MCI, even though these patients show increased amyloid pathology as assessed by Pittsburgh Compound B PET scans and hippocampal atrophy as assessed by volumetric analysis of MRI scans (282)