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The balance between anaerobic and aerobic lactate oxidation fluxes critically determines systemic lactate levels

Studies were included if CR, EX or CREX was one of the interventions

249,250 Acute systemic injections of the bacterial antigen lipopolysaccharide (LPS) in mice induces diffuse inflammatory changes in the CNS and mimics this sickness behaviour and is often used as a model to study effects of inflammation on CNS functions