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Mild injection site redness and swelling that resolves within days is common and usually not serious

These effects are thought to stem from slowed gastric emptying and changes in gut motility

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This lack of significant improvement may be attributed to the activation of VEGF-independent angiogenic pathways, the recruitment of proangiogenic stromal cells, the induction of vasculogenesis or even the dose of the antiangiogenic agent used, which may reduce the size of blood vessel pores, further obstructing the delivery of this antibody [30, 39, 40]