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For example, in both the STEP-1 and SURMOUNT-1 trials, patients attended regular counseling sessions to help with adherence to a reduced-calorie diet (500 cal/day deficit) and increased physical activity regimen ( 150 min/week) [21, 23]

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51,53 Furthermore, eGFR can be estimated using levels of a blood protein called cystatin C , which is produced at a constant rate by all nucleus-containing cells

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