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Insulin Therapy : In cases where oral medications are not sufficient to control blood sugar levels, insulin therapy may be necessary

Some agents: erythropoietin and MitoQ have shown protective effects in experimental models of renal IR (203, 204)

NEW FORMULATION Wegovy is now available as a once-daily oral pill FDA-approved oral GLP-1 Easy, once-daily pill ~14% weight loss at 1 year (similar to injectable) No injections or refrigeration needed Prescription & ongoing care through Healthspan 1 Based on the 64-week OASIS 4 Phase 3 clinical trial of 307 adults with obesity or overweight

and Elisabetta Patorno for their contribution to the peer review of this work