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A small, recent, surface-level macule on a phototype II will respond differently than a deep, decades-old macule on a phototype V, because the biology of these two situations is not the same

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CJC-1295 has been studied in both DAC and non-DAC forms for its GHRH receptor agonism and growth hormone pulse amplitude effects in preclinical models (Teichman et al., 2006, Journal of Clinical Endocrinology & Metabolism)