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The hypothesis that our study population had an aggressive form of MTC is also supported by the very low PFS in the present study, 0.7 years compared to 1.6 years in the placebo group of the phase III trial of the ZETA study (vandetanib) [4]

Two independent transfections were carried out, and resistant parasites were obtained following WR99210 selection (Figures 1F,G and Supplementary Table S3)

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