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Blocking activin type II receptors (ActRII) signaling by monoclonal antibody Bimagrumab combined with GLP-1 RA Semaglutide can reduce fat mass while potentially preserving lean mass- although this remains controversial (Nunn et al
Moreover, the complex pathogenesis of PD makes it a suitable target for GLP-1RAs, which modulate numerous intracellular signaling pathways, as demonstrated by in vitro and in vivo studies
Improvement of insulin resistance : GLP-1RA was shown to improve insulin signaling in the brain and promote glucose metabolism
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