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Edward Dosz, vice president of science and innovation at NutriScience Innovations (Milford, CT)

This insight helps your PlexusDx provider optimize semaglutide dosing or recommend alternative compounds like tirzepatide based on your unique genetic weight-regulation profile, avoiding the need for unproven drug combinations

Creatine causes intracellular water retention in muscle tissue, leading to initial weight gain of 2-4 pounds that may mask fat loss from tirzepatide on the scale

You should not use GLP-1 medications if you have: Personal or family history of medullary thyroid cancer Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Previous severe allergic reaction to semaglutide or liraglutide Current pregnancy or planning to become pregnant History of pancreatitis (requires careful evaluation) Severe gastrointestinal disease Additionally, these medications are not typically recommended for patients under 18 years old, though Saxenda has some pediatric approval for adolescents 12 and older with obesity