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Response: As readers are aware, we have been contemplating potential clinical APC assignments for the past number of rulemaking cycles but are not convinced as to what clinical APC would be appropriate in terms of clinical and resource homogeneity

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5-Amino-1MQ has shown metabolic benefits in preclinical trials, but no human studies or FDA evaluations currently exist. Hong et al., Nature Medicine Not Typically Screened for in Standard Drug Tests Standard athletic or employment drug tests (urine, hair, blood) do not test for 5-Amino-1MQ

A few commenters suggested stratifying performance reports based on SDOH-associated ICD-10 diagnoses or patient demographics