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Efruxifermin (AKR-001) Efruxifermin is an Fc-fusion FGF21 analogue with a terminal half-life of about 34 days, enabling once-weekly dosing

Extracellular signaling Even though mostly executing their functions intracellularly, there is a substantial portion of extracellular HSP70s released in endolysosomes, together with such proteins as cathepsin D and LAMP1 with the help of ATP-binding cassette transporters (Mambula et al., 2007), exosomes (Takeuchi et al., 2015) and microvesicles (Komarova et al., 2021)