That's exactly why it's included in topical skincare formulas: as an antioxidant that supports skin health and a healthier-looking glow over time, not as a tool for changing your natural complexion
In humans, GHK-Cu is proposed to promote wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts and promotion of blood vessels growth
It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)
their nitration resulting in a loss of c-met binding affinity of the ligand and thereby disturbs myogenic stem cell dynamics responsible for muscle homeostasis
