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Signs of a severe allergic reaction (anaphylaxis) include: Skin rash, hives, or severe itching Swelling of the face, lips, tongue, or throat Difficulty breathing or wheezing A rapid heartbeat or a sudden drop in blood pressure If you ever develop swelling of the face or throat, trouble breathing, or other signs of a severe reaction after any injection, treat it as an emergency and call 911

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For instance, taking over 7.5 g of acetaminophen (APAP) in a single dose can cause acute liver toxicity

1 It has been established that melatonin stimulates GPx in vivo , enhancing GPx activity, during which H 2 O 2 is metabolized to H 2 O, and glutathione (GSH) is oxidized to its disulfide form GSSG (Fig