According to a 2014 review published in The Lancet: Diabetes & Endocrinology , loss of muscle mass and strength is an important risk factor for accelerating rates of physical disability, hospitalization, and death in the older population, and is associated with the progressive health implications of diabetes, obesity, hyperthyroidism, hypercortisolism, vitamin D deficiency, osteoporosis, rheumatoid arthritis, COPD, congestive heart failure, renal disease and more
Common side effects may include: Increased hunger Water retention and joint stiffness Tingling or numbness in the extremities (carpal tunnel syndrome symptoms) Muscle aches Insulin resistance (a significant consideration that requires monitoring) Crucial Warning: The long-term safety of combining these peptides is not well-studied
Individuals with MTHFR variants needing extra methyl support
These findings highlight the importance of careful dose selection when evaluating PPRs safety and efficacy