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excess B12 is excreted in urine, and the UK has not established an upper safe limit

A single unusual case report did describe a life-threatening eosinophilic pneumopericardium effusion (a type of fluid accumulation around the lungs and heart with high eosinophil counts) in an elderly woman who had been concurrently taking high-dose pantothenic acid (vitamin B5 at 300 mg/day) and biotin (10 mg/day) for two months

This creates a beneficial cycle: better gut function supports better brain function, which in turn may improve gut-brain signaling

The horse has not received pain-relief and or anti-inflammatory medications for at least 48 hours and is comfortable