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METABOLISM CONTROLIS A BALANCE OF EATING MORE OR LESS IN RESPONSE TO THESE SIGNALING PEPTIDES Fat cells produce leptin which acts on the hypothalamus in the brain

Both principal degradants retain some in vitro anti-lipogenic activity, suggesting partial preservation of biological function through the oral digestion process

13 As our understanding of their mechanisms continues to evolve, these agents offer promising new avenues for improving outcomes in HF patients.