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10.1089/jmf.2012.2275 [DOI] [PMC free article] [PubMed] [Google Scholar] Li, M

the conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this unique family] iron sulfur domain 1 (CISD1)} is an outer mitochondrial membrane protein essential for sensing and regulation of iron and ROS homeostasis (Yuan et al., 2016

92 , 42J49J (2003)

Some amount of ROS is critical for normal T cell survival and maturation, and appropriate physiologic upregulation of ROS levels is needed for T cell receptor activation and downstream signaling that leads to T helper cell type 1 (Th1) differentiation and production of pro-inflammatory cytokines, such as IFN- and TNF- (63)