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Additional preclinical research has examined the compound in energy homeostasis, appetite suppression, and peripheral metabolic signalling models

The Gs heterotrimer engages with the receptor through the same interface observed in peptide-agonist structures, with the alpha-5 helix of Gs-alpha inserting into the intracellular cavity and making contacts with TM3, TM5, TM6, and intracellular loop 2 (ICL2)