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But it is how you own the patient journey: - Capture earlier-line patients who will never start an injection - Control the switch point if and when escalation happens - Reduce drop-off by offering de-escalation without losing the patient Most leaders wait for a competitor to force the disruption

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Furthermore, in 3T3-Ll adipocytes, GLP-1 stimulation improved insulin responsiveness by promoting increased glucose uptake and FA synthesis in adipose cells [80], possibly by CREB phosphorylation and ERK1/2 activation [81]

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