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Early studies demonstrated that intracerebroventricular (ICV) injection of H1R antagonists stimulated feeding ( Figure 3 More recently, global H1R knockout (H1R-KO) mice have been developed ( While the ability of histamine to suppress feeding is well demonstrated to occur via H1R, the exact neuronal populations and mechanisms responsible for these effects are not well understood

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In animal studies, Epitalon has been shown to reduce the incidence of certain tumors