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In some cases, individuals have reported depressive episodes beginning after dose escalation

Barini E, Antico O, Zhao Y, et al

The STEP 1 clinical trial demonstrated average weight loss of approximately 15% of initial body weight when combined with lifestyle modifications

In 2014, Ussher and colleagues inactivated GLP-1R in adult mouse cardiomyocytes and unexpectedly found that liraglutide administration after left anterior descending (LAD) artery occlusion induced increased heart rate and survival in these mice, although there was no difference in survival/adaptive responses or left ventricular remodelling following LAD coronary artery occlusion between GLP-1R inactivated and control mice that were not treated with any GLP-1R agonist