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Over half of the patients had tirzepatide dose de-escalation from 7.5 mg to 5 mg (28.6%) or from 5 mg to 2.5 mg (21.6%) (Fig

Some patients start with one form and transition to another as per their treatment response

Liraglutide received NICE approval (TA664) in 2020 for use through specialist weight management services, but the criteria are narrow, and availability has been limited in practice

Recent studies have revealed an autoregulatory mechanism whereby mitochondrial GSH (mtGSH) homeostasis is controlled through a feedback loop involving solute carrier family 25 member 39 (SLC25A39) transporter and mitochondrial protease AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), coupling GSH levels to iron-sulfur cluster biogenesis 16,17