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Tomasi, D

Conversely, higher concentrations of NT in the NAc increase dopamine release, which may be mediated by NTS1 on presynaptic dopaminergic terminals, and would be predicted to enhance the effects of psychostimulants (Figure 2A) (Reyneke et al., 1990

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Instead, they start at a very low initiation dose. The primary reason for a slow titration schedule is to allow the gastrointestinal (GI) system to adapt