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In the Phase 3 TRIUMPH-4 trial, a new safety signal called dysesthesia (abnormal skin sensations like tingling or burning) appeared in up to 20.9% of patients on the highest dose

Black realised the only way to find out was to test out his idea by developing a histamine antagonist in the same way as he had previously done with propranolol

When administered to the neck, it can boost collagen synthesis, improve skin elasticity, and thicken the dermis, leading to smoother, firmer, and more youthful-looking skin over timeespecially effective for treating the thinning and laxity caused by rapid fat loss

This is denoted by the lower right quadrant of the eDISH plot