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The commenter stated that the ReActiv8 ( has FDA approval [247] through the premarket process and is indicated for bilateral stimulation of the L2 medial branch of the dorsal ramus as it crosses the transverse process at L3 as an aid in the management of intractable chronic low back pain associated with multifidus muscle dysfunction, as evidenced by imaging or physiological testing in adults who have failed therapy including pain medications and physical therapy and are not candidates for spine surgery

It is a designation used primarily by the FDA (Food and Drug Administration) for products, often in vitro diagnostic (IVD) components like reagents or instruments, that are in the laboratory research phase of development and are not intended for clinical diagnostic use

BPC-157 works more locally, concentrating its signaling at the specific injury site

Mostly because its having a moment. BPC-157 has been a frequent guest on the Joe Rogan podcast, receives backing from Gary Brecka (a purveyor of nasal-sprayed BPC-157 for $375 a pop), and got a boost on Andrew Hubermans popular neuroscience-ish podcast