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Additionally, driving the 16-a-OHE1 pathway through 16-a-OHE1 to Estriol (via 16-hydroxylase activity) is another way to protect the tissues from estrogen dominance through weaker competitive binding of estriol at the ERs

Prokaryotic expression system and protein purification of HrGSTm1 A prokaryotic expression system was used to obtain recombinant HrGSTml (rHrGSTm1)

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Efficiacy results were analysed based on the reported efficacy estimand (calculated from data gathered while patients received their assigned randomized treatment, excluding data after discontinuing the allotted medication or after adding rescue medication