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Quick-Reference DDI Summary Table | Co-administered Drug | GLP-1 RA Effect | Clinical Action | |---|---|---| | Insulin (basal) | Additive hypoglycemia | Reduce insulin 20% to 40% at initiation | | Sulfonylurea | Additive hypoglycemia | Halve the dose at initiation | | Warfarin | Possible INR increase | Check INR at 2 to 4 weeks
For autoimmune research, longer cycles with gradual dose adjustments may be preferable to avoid the immune system fluctuations that abrupt changes can trigger
doi: 10.1038/nrrheum.2017.49 42 LiWXuMLiYHuangZZhouJZhaoQet al
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