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A plateau is typically defined as no measurable change over 3 to 4 weeks despite consistent adherence to treatment and lifestyle factors

Many preclinical pharmacological studies showed that Bromelain affected cell viability of cancer cells, however, the exact mechanisms of action produced by bromelain are rarely explored

The shotgun analysis yielded highly similar overall differences in microbiome signatures in the study groups as also identified by 16S sequencing (Figs 2A,B and 4A,B), further supporting the observation that liraglutide and GUB09-145 treatment resulted in larger microbiome compositional changes compared to vehicle-dosed DIO mice