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l-Arginine, which is converted to nitric oxide via nitric oxidase, stimulates the production of GLP-1, and dysregulation of l-arginine in obese patients leads to increased risk of airway inflammation and bronchoconstriction [85]

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doi: 10.1097/00000658-199104000-00008 57 SpolituSOkamotoHDaiWZadrogaJAWittchenESGromadaJet al

This redundancy means a patient is not getting two complementary weight loss tools but rather two separate pathways doing partially overlapping work, with increased side effect burden and no evidence of superior outcomes compared to either drug alone