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The initial step in designing a PCSK9/GLP-1 dual molecule was to fuse a DPP-4-resistant GLP-1 analogue peptide with either GGSA or [G 4 S] 3 A linkers to the heavy or light chain variable domains of a panel of anti-PCSK9 antibodies

Discovery of a potent and selective targeted NSD2 Degrader for the Reduction of H3K36me2

Incorporating These Medications into a Weight Loss Program Medications like Semaglutide and Tirzepatide are most effective when paired with a comprehensive weight loss program that includes dietary counseling, physical activity, and behavior modifications

Acknowledgements We acknowledge Erica Rurali, Ph.D