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Oxidative stress occurs when there's an imbalance between free radicals (unstable molecules that damage cells) and antioxidants (the molecules that neutralize them)

In this article, we review the mechanisms through which some metals and semi-metals of environmental, public health and occupational concern, and endowed with a chemical affinity to the thiolate form of sulphur present in glutathione and in cysteine-containing proteins may exert their toxic effect(s) in the living cell

Brooks JD, Paton VG, Vidanes G