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Nevertheless, still, it remains unclear whether these consequences of GIP in AT or fat metabolism are defensive or deleterious chronically

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Importantly, their effects go beyond simple calorie restriction

A new Cleveland Clinic analysis of nearly 8,000 patients suggests that discontinuing semaglutide and tirzepatide, on average, does not lead to significant weight regain in clinical practice, as many patients later restart the original medication or try an alternative obesity treatment