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It is a living organ with a complex structural framework made primarily of collagen and elastin fibers embedded in a gel-like substance called the extracellular matrix

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The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI

It is important to understand that while improving gut barrier function is increasingly used in the clinical setting as a therapeutic goal, the evidence is not yet there to support the efficacy of a single intervention in curing a disease by restoring or improving barrier function