The literature survey reveals that there exists some conventional analytical method development of these drugs individually through HPLC [3,4,5,6,7,8,9,10,11,12], UV [13,14,15] and HPTLC [16, 17]
Furthermore, GPER activation promotes the differentiation of preosteoblasts and increases the expression of mineralization markers, providing new therapeutic targets for osteoporosis
Metformins role may evolve from monotherapy dominance to an essential component of multidrug regimens optimized for individual patient needs
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