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c , Density for the ECD was visible in the cryo-EM and supports extended interactions of the ECD with ECL1 and ECL2, as well as with the ligand TT-OAD2

Because melanocortin modulation of energy homeostasis is centrally mediated, drug developers must overcome large pharmacokinetic hurdles for CNS penetration (53, 141)

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Quality control issues arise because the compound is sold only through unregulated channels with variable purity, potential contamination, and no manufacturing standards