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Other determinants of invasion are components and modulators of the HGF/c-Met pathway, such as metadherin in breast cancer and the metastasis-associated in colon cancer 1 ( MACC1 ) gene in colorectal carcinoma

The upregulation of this metabolic pathway because of the CAP or PTL treatment has also been observed in several different studies 56,57

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Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer