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B indicates RCTs without confirmatory meta-analysis

Over the past decade, gemcitabine has remained the standard first-line therapy for advanced PDAC, primarily exerting its effects by inducing DNA damage, promoting ROS accumulation, and triggering ferroptosis [153]

Gleixner KV, Schneeweiss M, Herrmann H, Blatt K, Berger D, Eisenwort G, Greiner G, Byrgazov K, Hoermann G, Konopleva M, Waliul I, Cumaraswamy AA, Gunning PT, Maeda H, Moriggl, R, Deininger M, Lion T, Andreeff M , Valent P