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Technology appraisal guidance TA664

Physiological function of glucagon-like peptide-1 (GLP-1)

The presence of GLP-1R in the phylogenetically oldest parts of the brain but not in the cortex emphasizes that GLP-1 is involved in the regulation of vital functions like feeding and satiety (141)

The pathophysiological processes of SLE tend to be stimulated by a dysfunction in the immune system, both the innate and adaptive, leading to various tissue injuries through cytokine release and the deposition of immune complexes[29]