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Thus, changes in these biomarkers do not accurately assess real-time brain function since the underlying and established deficits in neuronal functioning are unaffected by their absence

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An update literature review in 2022 (search dates: 06/2013 01/2021) identified 63 studies, 53 of which were added to the evidence base The Panel judged that these were a sufficient evidence base from which to construct the majority of the treatment portion of the guideline and algorithm

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