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pylori infection would be antibody mediated, especially mucosal sIgA
NICE has published guidance on pharmacological interventions for weight management, including NICE guideline CG189 (Obesity: identification, assessment and management) and a technology appraisal supporting the use of semaglutide (Wegovy) for adults with a BMI of 35 kg/m or above (or 3034.9 kg/m in certain circumstances) alongside a specialist weight management service
The FDA classifies semaglutide and tirzepatide as Category C medications, meaning animal reproduction studies have shown adverse effects, but no adequate human studies exist
Lead program TransCon aVEGF (EYC-0305) is in development for wet AMD and other retinal diseases, anticipated to enter the clinic in 2026
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