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How N-3 PUFAs specifically affected neuronal survival, how key the specific time window is within which nutrients are supplemented and whether other nutrients or the combination thereof might also modulate adult hippocampal neurogenesis in the context of ES remains to be determined

Furthermore, challenges such as low drug concentration at the local pathological site after systemic administration, limited target specificity and short drug half-life persist [6]

In addition, the same receptor expressed in different cell types can be desensitized by different mechanisms