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formerly polycystic ovary syndrome (PCOS), liraglutide increased butyrate-producing Lachnospiraceae and partially reversed dysbiosis, while semaglutide uniquely increased Helicobacter , the only taxon negatively correlated with body weight (31)

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Updated phase 3 titration pathway The phase 3 schedule uses the following escalation: Weeks 1-4: 2mg weekly Weeks 5-8: 4mg weekly Weeks 9-12: 8mg weekly Week 13+: Maintenance dose (4mg, 9mg, or 12mg depending on assignment) The introduction of a 9mg dose option is interesting

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