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Some medications reduce B12 absorption

IGF-1 LR3 and Biopharmaceutical Cell Culture Research Research conducted in industrially relevant CHO DP12 cell lines found that cells adapted to LONG R IGF-1 supplementation produced a twofold increase in recombinant protein yield compared to non-adapted cells, with a 40% increase in antibody titer versus insulin supplementation and a 62% increase relative to no growth factor findings that have informed its widespread adoption in serum-free biopharmaceutical manufacturing models

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Its overactivation disrupts nicotinamide metabolism, reduces NAD+ levels, promotes hepatic lipid accumulation and lipotoxicity, and represents an important therapeutic target for hepatic metabolic disorders