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3 Epigenetics Curcumin acts as a potent multi-target epigenetic modulator influencing gene expression through four major mechanisms: it inhibits DNA methyltransferases DNA (Cytosine-5)-Methyltransferase 1 DNA (Cytosine-5)-Methyltransferase 3 Alpha, DNA (Cytosine-5)-Methyltransferase 3 Beta (DNMT1, DNMT3A, DNMT3B), leading to demethylation and reactivation of silenced tumor-suppressor genes

As positive controls, PSCs were pre-incubated with Rosup reagent (Beyotime) for 20 min

Do not double the dose to compensate for a missed one

The exploration and investigation of GPxs, as key enzymes that regulate ROS levels in humans, is of great significance to elucidate the relationship between GPxs and diseases, including tumors, to further understand the pathogenesis of diseases and to prevent ameliorate and even cure these diseases